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Civatte bodies

MedGen UID:
90706
Concept ID:
C0333440
Anatomical Abnormality
Synonym: Colloid bodies
SNOMED CT: Hyaline body (18695008); Colloid bodies (18695008)
 
HPO: HP:0025115

Definition

Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue). They are 10-25 micrometers in diameter and situated mostly within or above the inflammatory cell infiltrate. In lichen planus, the number of necrotic keratinocytes may be so large that they are seen lying in clusters in the uppermost dermis. These bodies show a positive periodic acid Schiff reaction and are diastase resistant [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCivatte bodies

Conditions with this feature

Autosomal recessive inherited pseudoxanthoma elasticum
MedGen UID:
698415
Concept ID:
C1275116
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.

Recent clinical studies

Etiology

Sanches ACB, Pires ALPV, Medrado ARAP, de Almeida Reis SR, Freitas VS, Martins GB
Head Neck Pathol 2022 Dec;16(4):969-979. Epub 2022 May 17 doi: 10.1007/s12105-022-01442-9. PMID: 35579856Free PMC Article
Choksi YA, Chaparro J, Blanco M, Sharda R, Sarker S, Ferguson S, Higginbotham T, Hiremath G, Revetta F, Washington MK, Williams CS, Vaezi MF
Clin Gastroenterol Hepatol 2020 Jul;18(8):1727-1735.e2. Epub 2019 Oct 4 doi: 10.1016/j.cgh.2019.09.032. PMID: 31589979Free PMC Article
Flores S, Wada DA, Florell SR, Bowen AR
Am J Dermatopathol 2020 Jan;42(1):16-19. doi: 10.1097/DAD.0000000000001460. PMID: 31188140
Hadzi-Mihailovic M, Petrovic R, Raybaud H, Stanimirovic D, Ozar Koray M
J BUON 2017 Sep-Oct;22(5):1278-1286. PMID: 29135114
Panja SK, Banerjee PK
Indian J Dermatol 1989 Sep;34(3):47-53. PMID: 2632377

Diagnosis

Gajjar PC, Mehta HH, Nimbark V, Jethwa M
Australas J Dermatol 2018 Aug;59(3):e208-e210. Epub 2018 Mar 25 doi: 10.1111/ajd.12797. PMID: 29577239
Joshi R
Indian J Dermatol Venereol Leprol 2013 May-Jun;79(3):349-59. doi: 10.4103/0378-6323.110780. PMID: 23619439
Abraham SC, Ravich WJ, Anhalt GJ, Yardley JH, Wu TT
Am J Surg Pathol 2000 Dec;24(12):1678-82. doi: 10.1097/00000478-200012000-00014. PMID: 11117791
Brownstein MH, Silverstein L, Lefing W
J Am Acad Dermatol 1989 May;20(5 Pt 2):913-15. doi: 10.1016/s0190-9622(89)70106-7. PMID: 2715445
Person JR, Rogers RS 3rd
Arch Dermatol 1981 Nov;117(11):701-4. PMID: 7316529

Therapy

Sato Y, Takenaka R, Matsumi A, Takei K, Okanoue S, Yasutomi E, Kawai D, Takemoto K, Tsugeno H, Miyake T, Fujiki S
Intern Med 2018 Jan 1;57(1):25-29. Epub 2017 Oct 11 doi: 10.2169/internalmedicine.8668-16. PMID: 29021479Free PMC Article
Hadzi-Mihailovic M, Petrovic R, Raybaud H, Stanimirovic D, Ozar Koray M
J BUON 2017 Sep-Oct;22(5):1278-1286. PMID: 29135114
Menges M, Hohloch K, Pueschel W, Stallmach A
Digestion 2002;65(3):184-9. doi: 10.1159/000064939. PMID: 12138324
Carr A, Vasak E, Munro V, Penny R, Cooper DA
Clin Exp Immunol 1994 Aug;97(2):260-5. doi: 10.1111/j.1365-2249.1994.tb06078.x. PMID: 8050175Free PMC Article
Rotstein E, Rotstein H
Australas J Dermatol 1989;30(1):9-14. doi: 10.1111/j.1440-0960.1989.tb00400.x. PMID: 2535012

Prognosis

Dixit S, Jain P, Jain S, Gupta R, Grover C, Sharma S
J Cutan Pathol 2023 Oct;50(10):922-928. Epub 2023 Jul 10 doi: 10.1111/cup.14478. PMID: 37430417
Decker A, Schauer F, Lazaro A, Monasterio C, Schmidt AR, Schmitt-Graeff A, Kreisel W
World J Gastroenterol 2022 Nov 7;28(41):5893-5909. doi: 10.3748/wjg.v28.i41.5893. PMID: 36405107Free PMC Article
Hadzi-Mihailovic M, Cakic S, Jankovic S, Raybaud H, Nedeljkovic N, Jankovic L
J BUON 2012 Jan-Mar;17(1):132-7. PMID: 22517707
Abraham SC, Ravich WJ, Anhalt GJ, Yardley JH, Wu TT
Am J Surg Pathol 2000 Dec;24(12):1678-82. doi: 10.1097/00000478-200012000-00014. PMID: 11117791

Clinical prediction guides

Dixit S, Jain P, Jain S, Gupta R, Grover C, Sharma S
J Cutan Pathol 2023 Oct;50(10):922-928. Epub 2023 Jul 10 doi: 10.1111/cup.14478. PMID: 37430417
Sanches ACB, Pires ALPV, Medrado ARAP, de Almeida Reis SR, Freitas VS, Martins GB
Head Neck Pathol 2022 Dec;16(4):969-979. Epub 2022 May 17 doi: 10.1007/s12105-022-01442-9. PMID: 35579856Free PMC Article
Flores S, Wada DA, Florell SR, Bowen AR
Am J Dermatopathol 2020 Jan;42(1):16-19. doi: 10.1097/DAD.0000000000001460. PMID: 31188140
Ponce-Olivera RM, Tirado-Sánchez A, Montes-de-Oca-Sánchez G, León-Dorantes G, Mercadillo-Pérez P
Int J Dermatol 2007 May;46(5):490-1. doi: 10.1111/j.1365-4632.2007.02964.x. PMID: 17472678
Ebner H, Gebhart W
J Cutan Pathol 1976;3(4):167-74. doi: 10.1111/j.1600-0560.1976.tb00858.x. PMID: 63473

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